Epstein-Barr virus gp350 envelope glycoprotein, illustration - stock illustration

Illustration of the X-ray structure of the Epstein-Barr virus (EBV) glycoprotein gp350, which plays a key role in infecting B cells. The protein is covered by a glycan shield, a layer of sugar molecules that helps the virus evade the immune system. Despite this protective coating, a specific region remains exposedâ€\the CR2 receptor-binding siteâ€\"which allows gp350 to attach to B cells and initiate infection. Visualising this structure helps scientists understand how EBV recognises its host cells and how the virus balances immune evasion with receptor engagement. These insights are important for designing vaccines and therapeutic strategies that target viral entry